Growth Hormone Releasing Peptide (GHRP)

Growth Hormone Releasing Peptide 2 (GHRP2): Is a synthetic six amino acid peptide that has robustly potent properties. GHRPs are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH) through the activation of a specific, G protein-coupled receptor. They were discovered 20 years ago as synthetic metenkephalin- derived oligopeptides (Synthetic tissue derived amino acids). Although it has no structural homology with Growth Hormone Releasing Hormone (GHRH), in clinical studies GHRP-2 demonstrated action on the pituitary to release Human Growth Hormone (HGH).

GHRP-6 is a peptide in the growth factor family. It has strong effect on the release of Growth Hormone (GH). Its main use is to promote food intake by stimulating hunger and aid in energy metabolism. It can be used in the treatment of GH deficiency as well as cachexia, eating disorders and obesity. The major side effect accompanied by the use of GHRP-6 is a significant increase in appetite due to a stimulating the release of Ghrelin, a peptide which is released naturally in the lining of the stomach and increases hunger and gastric emptying.

GHRP-6 causes stimulation of the anterior pituitary gland which ultimately causes an increase in GH release. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release, when natural GH secretion has been inhibited by long term synthetic use, GHRP-6 can be used to re-stimulate the natural production of GH. GHRP-6 also affects the central nervous system, by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do.

Benefits of increased Growth Hormone levels through GHRP-6 stimulation include: an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the primary anabolic mechanism of action for Growth Hormone.