Clomiphene Citrate (Clomid)

Clomiphene citrate or Clomid is a selective estrogen receptor modulator (SERM) that increases production of gonadotropins by inhibiting negative feedback on the hypothalamus. Clomiphene citrate is marketed under various trade names including Clomid, Serophene, and Milophene.

It is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, thereby blocking the effects of estrogen, such as gynecomastia. It also restores the body's natural production of testosterone. It is commonly used as a "recovery drug" and taken toward the end of a steroid cycle.

Clomiphine citrate has been found very effective in the treatment of secondary male hypogonadism in many cases. Because clomiphene citrate has not been FDA approved for use in males it is prescribed off-label. According to Professor Craig Niederberger, because this drug is now generic, no drug company would pursue FDA approval for use in men now because there would be no profit incentive. However, the single isomer of clomiphine "enclomiphene" under the brand name Androxal is currently under phase 2 trials for use in men.